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. 2010 Nov 25;300(2):G217–G227. doi: 10.1152/ajpgi.00356.2010

Fig. 8.

Fig. 8.

Effects of JMV-180 on CCK- and leptin-induced c-Fos expression in rat nodose ganglion. Triple fluorescence labeling of rat nodose ganglia shows c-Fos-positive neuronal nuclei (red), CCKAR (blue), and OB-Rb (green). A: c-Fos expression in nodose ganglion in response to intraperitoneal (IP) injection of CCK-8 (3.5 μg/kg) and leptin (120 μg/kg). B: c-Fos expression in nodose ganglion treated with JMV-180 (350 μg/kg ip) 15 min before IP injection of CCK-8 (3.5 μg/kg) and leptin (120 μg/kg). JMV-180 reduced c-Fos-IR in the nodose ganglion. Scale bar: 100 μm. C: histogram shows percentage of neurons that exhibited c-Fos immunoreactivities over the total number of neurons in the nodose ganglion (n = 3). Note that JMV-180 significantly reduced c-Fos expression in the neurons expressing CCKAR and those expressing both CCKAR and OB-Rb. *P < 0.01 compared with no pretreatment with JMV-180.