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. 2010 Dec 24;20(6):1111–1121. doi: 10.1093/hmg/ddq555

Figure 1.

Figure 1.

Levels of p-AMPK and PGC-1α in the brain of WT mice, their Ppt1-KO littermates and in INCL fibroblasts. (A) Western blot analysis of phosphorylated-AMPK (p-AMPK) and total AMPK levels in the brain tissues from 1-, 3- and 6-month WT mice and their Ppt1–KO littermates; (B) western blot analysis of p-AMPK levels in normal (N, left lane) and INCL patient fibroblasts (right lane); (C) western blot analysis of PGC-1α levels in the nuclear fractions of brain tissues from 1-, 3- and 6-month WT mice and their Ppt1-KO littermates; (D) western blot analysis of PGC-1α in the nuclear fraction from normal human fibroblasts (N) and in that of INCL patient fibroblasts (lanes 1, 2 and 3). TATA box-binding protein (TBP) was used as loading standard for nuclear protein extracts.