Figure 1.

Manhattan plot showing association between methylation at individual CpG sites and chronological age. Plotted are P-values indicating strength of association between DNA methylation levels at >27 000 CpG sites and age in cerebellum (purple), frontal cortex (green), pons (blue) and temporal cortex (red). For each point, a positive association between DNA methylation and chronological age is indicated by upward pointing triangles; a negative association is indicated by downward pointing triangles.