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Covariate-adjusted methylation levels in cerebellum (purple), frontal cortex (green), pons (blue) and temporal cortex (red) for 10 CpG sites where methylation levels increase significantly with age in all four brain regions (based on a Bonferroni threshold for significance of P = 1.8 × 10−6). Notably for all 10 loci that met our conservative threshold for significance, methylation levels were positively associated with age.
