Figure 4.

Ternary plots showing concordance of combined P-values from phase I analyses across all four brain regions stratified by CpG island or non-island status. (A–H) The combined magnitude of association per CpG site for all possible combinations of brain regions. The cumulative log₁₀ P-value is the additive combination of P-values (transformed to a −log₁₀ scale) across three brain regions spatially indicated in the ternary plots. For each side of the ternary plots, the 0–1 scale is related to the untransformed P-values, with each side labeled per brain region analyzed in the discovery phase of analyses. These plots show that most robust associations, with the largest combined P-values across multiple brain regions (on the −log₁₀ scale) occur at CpG islands.