Figure 5.

Data from stage II comparing results from cerebellum and frontal cortex, showing that significant results across two or more tissues often occur at similar methylation levels across various tissues, seemingly robust to the magnitude of methylation. (A) The dispersion of all results in stage II across varying levels of methylation in both tissue types regardless of statistical significance, whereas (F) presents the same data but also overlays the subsets of the data shown in (B)–(E). (B)–(E) describe subsets of results significant across a number of brain regions evident in the panel labels within the figure. The cumulative log₁₀ P-value is the additive combination of P-values (transformed to a −log₁₀ scale) across brain regions for the same CpG site.