. 2010 Nov 12;300(2):L167–L175. doi: 10.1152/ajplung.00277.2010

Table 1.

Changes in protein concentrations, oncotic pressures, urine output, fluid balance, hematocrit, and hemoglobin

	Time After Injury, h
	0	3	6	12	18	24
C_P, g/dl
Sham	4.9 ± 0.2	4.6 ± 0.2	4.7 ± 0.2	4.6 ± 0.1	4.8 ± 0.2	4.9 ± 0.2
Control	4.9 ± 0.3	3.7 ± 0.2^*	3.6 ± 0.2^*	3.2 ± 0.2^*	2.7 ± 0.2^*	2.7 ± 0.2^*
INO-4885	5.1 ± 0.1	3.8 ± 0.2^*	3.8 ± 0.1^*	3.8 ± 0.1^*^†	4.0 ± 0.2^*^†	3.8 ± 0.1^*^†
C_L, g/dl
Sham	3.5 ± 0.3	3.2 ± 0.2	3.0 ± 0.3	3.4 ± 0.3	3.4 ± 0.2	3.1 ± 0.3
Control	3.3 ± 0.1	2.6 ± 0.2	2.1 ± 0.1^*	2.0 ± 0.0^*	1.8 ± 0.1^*	1.6 ± 0.1^*
INO-4885	3.9 ± 0.2	2.9 ± 0.2	2.4 ± 0.3	2.5 ± 0.2^*	2.4 ± 0.3^*	2.3 ± 0.3^*^†
π_P, mmHg
Sham	23.4 ± 1.0	21.8 ± 1.0	22.1 ± 0.9	23.2 ± 1.1	22.8 ± 1.2	22.7 ± 0.8
Control	21.5 ± 0.6	15.3 ± 0.8^*	14.4 ± 0.6^*	13.4 ± 0.4^*	12.2 ± 0.6^*	10.7 ± 0.7^*
INO-4885	23.1 ± 0.4	16.6 ± 0.6^*	16.4 ± 0.9^*	16.6 ± 1.0^*^†	16.1 ± 1.1^*^†	15.2 ± 1.2^*^†
π_L, mmHg
Sham	13.9 ± 0.12	11.8 ± 1.0	11.8 ± 0.8	13.1 ± 1.1	13.4 ± 0.7	13.0 ± 0.7
Control	13.6 ± 0.5	10.6 ± 0.8	9.3 ± 0.6	9.1 ± 0.3^*	8.8 ± 0.5^*	6.9 ± 0.3^*
INO-4885	15.0 ± 0.9	11.4 ± 0.7	9.5 ± 0.8	10.4 ± 0.9^*	9.8 ± 0.8^*	9.4 ± 1.0^*^†
C_L/C_P
Sham	0.72 ± 0.03	0.71 ± 0.04	0.66 ± 0.05	0.77 ± 0.06	0.74 ± 0.03	0.66 ± 0.04
Control	0.68 ± 0.03	0.71 ± 0.06	0.60 ± 0.04	0.64 ± 0.04	0.69 ± 0.06	0.61 ± 0.07
INO-4885	0.76 ± 0.04	0.77 ± 0.06	0.63 ± 0.06	0.65 ± 0.05	0.60 ± 0.05	0.61 ± 0.06
π_L/π_P
Sham	0.61 ± 0.04	0.57 ± 0.04	0.56 ± 0.03	0.59 ± 0.04	0.62 ± 0.03	0.60 ± 0.03
Control	0.63 ± 0.02	0.69 ± 0.03^*	0.64 ± 0.02	0.68 ± 0.02	0.74 ± 0.06^*	0.66 ± 0.02
INO-4885	0.69 ± 0.03	0.69 ± 0.02^*	0.58 ± 0.03	0.62 ± 0.03	0.61 ± 0.04^†	0.62 ± 0.04
LPC, ml/h
Sham	4 ± 0	4 ± 1	3 ± 0	4 ± 1	4 ± 1	3 ± 1
Control	4 ± 0	11 ± 3^*	18 ± 3^*	25 ± 4^*	27 ± 3^*	34 ± 4^*
INO-4885	4 ± 0	4 ± 1^†	5 ± 1^†	9 ± 2^†	10 ± 3^†	14 ± 6^*^†
Urine output, ml/kg
Sham		16.9 ± 3.3	26.4 ± 4.1	33.4 ± 5.6	26.7 ± 4.5	27.7 ± 3.9
Control		5.9 ± 1.3^*	10.8 ± 1.2^*	19.5 ± 3.1^*	5.6 ± 1.0^*	5.1 ± 1.5^*
INO-4885		8.3 ± 2.4^*	7.6 ± 0.9^*	18.9 ± 4.1^*	15.3 ± 3.3^*^†	16.0 ± 5.2^*^†
Net fluid balance, ml/kg
Sham		5.3 ± 1.9	7.5 ± 4.1	11.8 ± 5.5	5.9 ± 3.5	2.3 ± 3.8
Control		16.1 ± 3.1^*	35.1 ± 3.8^*	54.5 ± 6.8^*	71.7 ± 7.8^*	86.1 ± 8.9^*
INO-4885		20.1 ± 2.3^*	43.2 ± 2.6^*	67.8 ± 7.0^*	79.8 ± 7.0^*	88.1 ± 9.7^*
Hct, %
Sham	28 ± 1	27 ± 1	26 ± 1	26 ± 1	27 ± 1	26 ± 1
Control	28 ± 1	32 ± 2^*	31 ± 2^*	29 ± 1	32 ± 2^*	35 ± 2^*
INO-4885	28 ± 1	30 ± 1	28 ± 2	28 ± 2	29 ± 2	29 ± 2^†
Hb, g/dl
Sham	10.0 ± 0.2	9.3 ± 0.2	9.1 ± 0.3	9.2 ± 0.3	9.6 ± 0.3	9.5 ± 0.4
Control	9.7 ± 0.3	11.9 ± 0.9^*	10.6 ± 0.6	10.1 ± 0.5	10.9 ± 0.6	11.3 ± 0.7^*
INO-4885	9.5 ± 0.4	10.6 ± 0.6	9.5 ± 0.5	9.4 ± 0.6	9.6 ± 0.6	9.8 ± 0.5^†

Values are means ± SE. C_P, plasma protein concentration; C_L, lymph protein concentration; π_P, plasma colloid oncotic pressure; π_L, lymph colloid oncotic pressure; Hct, hematocrit; LPC, lymph protein clearance.

P < 0.05 vs. sham.

^†

P < 0.05, INO-4885 vs. control.