Table 2.
Changes in cardiopulmonary variables
| Time After Injury, h |
||||||
|---|---|---|---|---|---|---|
| 0 | 3 | 6 | 12 | 18 | 24 | |
| MAP, mmHg | ||||||
| Sham | 104 ± 3 | 113 ± 5 | 112 ± 3 | 111 ± 3 | 103 ± 2 | 102 ± 2 |
| Control | 98 ± 3 | 109 ± 3 | 110 ± 3 | 108 ± 3 | 98 ± 3 | 98 ± 5 |
| INO-4885 | 102 ± 3 | 110 ± 3 | 115 ± 4 | 115 ± 3 | 113 ± 5 | 111 ± 6 |
| SVRI, dyn·s·cm−5·m−2 | ||||||
| Sham | 1,212 ± 49 | 1,153 ± 60 | 1,218 ± 68 | 1,294 ± 64 | 1,273 ± 83 | 1,219 ± 52 |
| Control | 1,184 ± 59 | 1,434 ± 122 | 1,383 ± 105 | 1,391 ± 87 | 1,306 ± 81 | 1,339 ± 89 |
| INO-4885 | 1,363 ± 125 | 1,688 ± 179 | 1,542 ± 175 | 1,656 ± 195 | 1,425 ± 104 | 1,314 ± 89 |
| HR, beats/min | ||||||
| Sham | 98 ± 3 | 103 ± 6 | 100 ± 5 | 101 ± 5 | 106 ± 7 | 102 ± 3 |
| Control | 96 ± 5 | 136 ± 11* | 128 ± 8* | 141 ± 10* | 145 ± 11* | 153 ± 7* |
| INO-4885 | 97 ± 1 | 120 ± 8 | 104 ± 7*† | 104 ± 5*† | 112 ± 4*† | 119 ± 4*† |
| CI, l·min−1·m−2 | ||||||
| Sham | 6.5 ± 0.1 | 6.9 ± 0.2 | 6.7 ± 0.3 | 6.5 ± 0.2 | 6.1 ± 0.3 | 6.2 ± 0.2 |
| Control | 6.1 ± 0.4 | 5.9 ± 0.6 | 6.0 ± 0.4 | 5.9 ± 0.4 | 5.7 ± 0.6 | 5.4 ± 0.5 |
| INO-4885 | 5.8 ± 0.4 | 5.8 ± 0.3 | 5.8 ± 0.5 | 5.4 ± 0.5 | 6.0 ± 0.4 | 6.3 ± 0.4 |
| LAP, mmHg | ||||||
| Sham | 9 ± 1 | 11 ± 1 | 11 ± 1 | 11 ± 1 | 11 ± 1 | 10 ± 1 |
| Control | 9 ± 1 | 8 ± 1 | 10 ± 1 | 9 ± 1 | 10 ± 1 | 11 ± 1 |
| INO-4885 | 8 ± 1 | 9 ± 1 | 12 ± 1 | 11 ± 1 | 11 ± 1 | 10 ± 1 |
| SVI, ml·beat−1·m−2 | ||||||
| Sham | 67 ± 2 | 68 ± 6 | 65 ± 5 | 65 ± 2 | 59 ± 4 | 61 ± 2 |
| Control | 64 ± 2 | 46 ± 6* | 48 ± 5* | 42 ± 3* | 39 ± 3* | 36 ± 3* |
| INO-4885 | 60 ± 4 | 42 ± 3* | 56 ± 4* | 51 ± 3* | 54 ± 5† | 53 ± 4† |
| LVSWI, g·m−1·m−2 | ||||||
| Sham | 85 ± 3 | 93 ± 6 | 93 ± 6 | 89 ± 5 | 73 ± 5 | 77 ± 3 |
| Control | 76 ± 3 | 62 ± 8* | 66 ± 6* | 57 ± 5* | 48 ± 4* | 43 ± 5* |
| INO-4885 | 76 ± 3 | 58 ± 3* | 79 ± 3 | 72 ± 4* | 75 ± 8† | 73 ± 6† |
| MPAP, mmHg | ||||||
| Sham | 20 ± 1 | 25 ± 2 | 26 ± 0 | 25 ± 0 | 24 ± 0 | 24 ± 1 |
| Control | 20 ± 1 | 26 ± 1 | 27 ± 1 | 30 ± 2* | 28 ± 1 | 30 ± 2* |
| INO-4885 | 21 ± 0 | 24 ± 1 | 25 ± 1 | 28 ± 2 | 27 ± 1 | 29 ± 2* |
| PVRI, dyn·s·cm−5·m−2 | ||||||
| Sham | 102 ± 5 | 106 ± 7 | 135 ± 11 | 118 ± 10 | 131 ± 9 | 116 ± 8 |
| Control | 115 ± 13 | 149 ± 11* | 158 ± 14 | 201 ± 17* | 170 ± 26 | 193 ± 18* |
| INO-4885 | 140 ± 10 | 145 ± 20* | 142 ± 21 | 185 ± 22* | 159 ± 20 | 170 ± 21* |
Values are means ± SE. MAP, mean arterial pressure; SVRI, systemic vascular resistance index; HR, heart rate; CI, cardiac index; LAP, left atrial pressure; SVI, stroke volume index; LVSWI, left ventricular stroke work index; MPAP, mean pulmonary arterial pressure; PVRI, pulmonary vascular resistance index.
*
P < 0.05 vs. sham.
†
P < 0.05, INO-4885 vs. control.