Table 1.
Histologic Findings in SIV-Infected and SHIV-Infected Macaquesa
| Animal | Species | Viral strain | Duration of infection (months) | Pulmonary vascular lesions | Lung pathologies |
|---|---|---|---|---|---|
| 2700 | Macaca mulatta | SIV ΔB670 | 24 | None | PCP, possible lung metastases of distant tumor |
| 2800 | Macaca mulatta | SIV ΔB670 | 21.5 | Vacuolar change | PCP |
| 3000 | Macaca mulatta | SIV ΔB670 | 45 | Vacuolar change | Persistently Pc colonized |
| 3200 | Macaca mulatta | SIV ΔB670 | 8.5 | None | PCP |
| 6697 | Macaca mulatta | SIV ΔB670 | 27.5 | Plexiform lesion, Small artery and Medium artery intimal hyperplasia, Vacuolar change | PCP |
| 10797 | Macaca mulatta | SIV ΔB670 | 24 | None | Mild PCP |
| 8299 | Macaca mulatta | SIV ΔB670 | 11.5 | Medium artery medial hyperplasia, vacuolar change | |
| 8799 | Macaca mulatta | SIV ΔB670 | 17 | Medium artery intimal hyperplasia | Acute PCP |
| 12099 | Macaca mulatta | SIV ΔB670 | 13.5 | Vacuolar change | PCP |
| 1700 | Macaca mulatta | SIV ΔB670 | 23 | Large artery intimal hyperplasia | Persistently Pc colonized |
| 11405 | Macaca fasicularis | SHIV-env (89.6P) | 15 | None | Pc colonized |
| 11505 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Large artery intimal hyperplasia, vacuolar change | Pc colonized |
| 11605 | Macaca fasicularis | SHIV-env (89.6P) | 12.25 | Large artery intimal hyperplasia, vacuolar change | |
| 11705 | Macaca fasicularis | SHIV-env (89.6P) | 12.25 | Vacuolar change | |
| 11805 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Large artery intimal and medial hyperplasia | Questionable Pc colonization status |
| 15405 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Vacuolar change | Pc colonized |
| 15505 | Macaca fasicularis | SHIV-env (89.6P) | 15 | None | Pc colonized |
| 15605 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Medium artery medial hyperplasia | Pc colonized |
| 15705 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Medium artery medial hyperplasia, large artery intimal hyperplasia | Pc colonized |
| 15905 | Macaca fasicularis | SHIV-env (89.6P) | 12.25 | None | |
| 16005 | Macaca fasicularis | SHIV-env (89.6P) | 12.25 | Small artery hyperplasia, large artery intimal and medial hyperplasia, plexiform lesion | |
| 16105 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Small artery hyperplasia, large artery intimal and medial hyperplasia, vacuolar change | Pc colonized |
| 16305 | Macaca fasicularis | SHIV-env (89.6P) | 15 | Plexiform lesion, vacuolar change | Pc colonized |
a
Pc, pneumocystis; PCP, pneumocystis pneumonia.