FIG. 2.

S1P₁, S1P₃ activation with FTY720 enhances microvascular remodeling in window chamber. Intravital microscopy images of poly(D, L-lactic-co-glycolic acid) (PLAGA) films loaded with FTY720, VPC01091, S1P+JTE013, or S1P+VPC44116 in the dorsal skinfold window chamber at 0 and 7 days postimplantation of films. Substantial increases in new vascular growth are seen in response to FTY720. VPC01091, JTE013, and VPC44116 decrease functional length density over 7 days. Examples of venules are denoted by white arrows, and arterioles by black arrows. Blood column width is the diameter of the blood vessels as seen in intravital images and used to quantify changes in vessel diameter. Scale bar = 500 μm. Color images available online at www.liebertonline.com/ten.