FIG. 4.

Effect of S1P receptor signaling modulation on functional length density after 3 (gray bars) and 7 (black bars) days of treatment with 1 mm PLAGA control films or PLAGA films loaded with S1P agonists and antagonists. S1P₁, S1P₃-selective agonism with FTY720 significantly increased functional microvascular length density. Bars from left to right: PLAGA, S1P, FTY720, VPC01091, S1P+JTE013, and S1P+VPC44116. *p < 0.05, significant to all other groups within respective time period (days 0–3, days 0–7).