Table 2.

Role of tissue factor (TF) in venous and microvascular thrombosis models.

Thrombotic method	Vascular location	Animal species	Inhibitor/gene	TF dependent	Study description	Reference
Ligation	IVC	N-H Primate	PHA-796	Yes	Thrombosis was inhibited in a dose-dependent manner	66
Ligation	IVC	Rat	anti-TF Ab	Yes	Inhibition of TF abolished thrombosis from MVs collected from cardiac surgery patients	67
Ligation	IVC	Mouse	Low TF gene	Yes	Low TF mice were protected from venous thrombosis	9
Collagen-coated thread	Jugular Vein	Rabbit	anti-TF Ab	Yes	Inhibition of TF significantly downregulates fibrin accumulation	68
Laser injury	Cremaster arterioles	Mouse	Low TF gene	Yes	Inhibition of thrombus formation displaying small platelet thrombi lacking TF or fibrin	74
Laser injury	Cremaster arterioles	Mouse	Low TF gene	Yes	TF-bearing MVs derived from haematopoietic cells initiate thrombus formation	75

Abbreviations: N-H: non-human; Ab: antibody; PHA-927: TF:FVII complex inhibitor