Table 3.

Role of tissue factor (TF) in models of disseminated intravascular coagulation (DIC).

Thrombotic method	Vascular location	Animal species	Inhibitor/gene	TF dependent	Study description	Reference
Endotoxin or TF Injection	Blood analysis	Rabbit	Polyclonal rabbit TF Ab	Yes	DIC was attenuated, however, endotoxic shock remained unchanged	92
Endotoxin injection	Blood analysis	Baboons	mAb TF	Yes	Protected against DIC activation of coagulation	87
Endotoxin injection	Blood analysis	Baboons	rTFPI	Yes	Activation of coagulation, measured by TAT, inhibited and decreased IL-6	88
Endotoxin injection	Blood analysis	Baboons	FVIIai	Yes	Activation of coagulation inhibited, as well as IL-6 and IL-8, but not TNF-α	89
Endotoxin injection	Blood analysis	Chimps	mAb TF	Yes	Activation of coagulation inhibited, but no effect on IL-6 or TNF-α cytokines	90
Endotoxin injection	Blood analysis	Chimps	mAb FVII/FVIIa	Yes	DIC-induced coagulation inhibited	91
Endotoxin injection	Blood analysis	Mouse	Low TF Gene	Yes	Low TF mice are protected from endotoxaemia activation of coagulation	93
Endotoxin injection	Blood analysis	Mouse	LysM and Tie2 Cre TF Flox deletion	Yes	Conditional deletion of myeloid TF protects against endotoxaemia-induced coagulation	94

Abbreviations: mab: monoclonal antibody; FVIIai: active site inhibitor of FVII; r: recombinant