Table 3.
Potential Predictors of Sustained Viral Response Were Compared
| SVR | No SVR | P value | |
|---|---|---|---|
| IL28Brs12979860 | 54.3% CC; 39.2% CT; 6.5% TT | 32.6% CC; 45.7% CT; 21.7% TT | 0.038 |
| Gender | 71.8% male | 78.6% male | 0.49 |
| Race | 3 African-American | 15 African American | 0.006 |
| 59 Caucasian | 56 Caucasian | ||
| Age (years) | 47.0 ± 12.0 | 51.6 ± 9.4 | 0.063 |
| Hepatic activity index | 5.4 ± 1.6 | 6.5 ± 2.9 | 0.12 |
| Fibrosis score | 2.4 ± 1.8 | 3.1 ± 1.7 | 0.20 |
| Fibrosis score of 5 or 6 | 13% | 29% | 0.13 |
| AST (IU/L) | 77.8 ± 53.9 | 67.9 ± 41.0 | 0.36 |
| ALT (IU/L) | 123.2 ± 110.9 | 87.4 ± 71.3 | 0.11 |
| Platelets (thousand/μL) | 226.9 ± 57.0 | 205.6 ± 82.7 | 0.20 |
| HCV genotype | 31 genotype 1 | 67 genotype 1 | <0.0001 |
| 31 genotype 2/3 | 4 genotype 2/3 | ||
| Brand | 31 PEG-IFN-α-2b | 41 PEG-IFN-α-2b | 0.44 |
| 31 PEG-IFN-α-2a | 30 PEG-IFN-α-2a | ||
| Baseline BDI-II score | 5.7 ± 5.5 | 6.6 ± 6.3 | 0.50 |
| SSRI during treatment | 42.5% prescribed an SSRI | 41.5% prescribed an SSRI | 0.93 |
The 3 predictors meeting statistical significance (bold) in this group are IL28B genotype, viral genotype, and race.
IFN, interferon; SVR, sustained viral response; PEG, pegylated.