. 2011 Feb;300(2):F574–F580. doi: 10.1152/ajprenal.00150.2010

Table 1.

Comparison of 24-h water intake, urine volume, urinary concentrations of BUN, creatinine, sodium and potassium, C_Creatinine, and FE_Na⁺ between Bbs2^−/−, Bbs4^−/− mice, and WT controls

Genotype	Water Intake, ml	U_Vol, ml	U_BUN, mg/dl	U_Creatinine, mg/dl	C_Creatinine, μl/min	U_Na⁺, mmol/l	FE_Na⁺, %	U_K+, mmol/l
WT	2.94 ± 0.54	0.90 ± 0.13	3,467 ± 160	57 ± 2	208 ± 8	83 ± 8	0.16 ± 0.02	217 ± 12
Bbs2^−/−	2.25 ± 0.23	0.38 ± 0.07^*	4,326 ± 329	85 ± 7^*	116 ± 10^*	123 ± 15	0.19 ± 0.02	244 ± 24
Bbs4^−/−	2.45 ± 0.15	0.36 ± 0.08^*	5,301 ± 355^*	72 ± 3^*	104 ± 5^*	199 ± 17^*	0.31 ± 0.03^*	358 ± 20^*

Values are means ± SE. BUN, blood urea nitrogen; C_Creatinine, clearance of creatinine; FE_Na⁺, fractional excretion of sodium; Bbs, Bardet-Biedl syndrome; WT, wild-type controls.

P < 0.05 compared with WT mice; n = 8-18 per group.