p75NTR IR in urothelium (U) (A–F) and detrusor smooth muscle (sm) (A, B, D, E) of littermate WT (A–C) and NGF-OE (D–F) mice. Comparable p75NTR IR was present in urothelial cells of WT and NGF-OE urothelium (A–F). p75NTR IR was expressed in detrusor sm of WT mice (A, B) and increased in detrusor sm of NGF-OE mice (D, E). L, lumen. Calibration bar: 50 μm (B, C, E, F), 125 μm (A, D). G: summary histogram of p75NTR expression in the U and detrusor sm in WT and NGF-OE mice. Values are means ± SE for n = 5–7. *P ≤ 0.01.