Table 4.
Parameter | Definition | Value |
---|---|---|
k1sGC | Eb-NO forward rate | 2.0 × 109 M−1·s−1 |
k−1sGC | Eb-NO backward rate | 100 s−1 |
k2sGC | E6c forward rate | 0.1 s−1 |
k3sGC | E6c-NO forward rate | 3 × 106 M−1·s−1 |
K4sGC | E5c forward rate | 9.8 × 104 M−1·s−1 |
Vmax, sGC | cGMP maximal production rate | 1.09 μM·s−1 |
kPDE | cGMP hydrolysis rate constant | 0.032 s−1 |
KM, PDE | cGMP hydrolysis constant | 2.0 μM |
Eb is the basal form of sGC, E6c is an intermediate complex, and E5c is the fully activated form of sGC. Values are taken from Ref. 53.