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. 2010 Nov 17;300(2):F441–F456. doi: 10.1152/ajprenal.00499.2010

Table 4.

Parameters related to sGC and cGMP kinetics (Eqs. 1823)

Parameter Definition Value
k1sGC Eb-NO forward rate 2.0 × 109 M−1·s−1
k−1sGC Eb-NO backward rate 100 s−1
k2sGC E6c forward rate 0.1 s−1
k3sGC E6c-NO forward rate 3 × 106 M−1·s−1
K4sGC E5c forward rate 9.8 × 104 M−1·s−1
Vmax, sGC cGMP maximal production rate 1.09 μM·s−1
kPDE cGMP hydrolysis rate constant 0.032 s−1
KM, PDE cGMP hydrolysis constant 2.0 μM

Eb is the basal form of sGC, E6c is an intermediate complex, and E5c is the fully activated form of sGC. Values are taken from Ref. 53.

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