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. 2010 Nov 17;300(2):F441–F456. doi: 10.1152/ajprenal.00499.2010

Table 5.

Parameters related to NO- and ROS-mediated effects on Ca2+ signaling

Parameter Definition Value Reference
KM, cGMPMLCP cGMP concentration at half-maximal activation of MLCP (Eq. 25) 5.5 μM 53
KM, cGMPSERCA cGMP concentration at half-maximal activation of SERCA (Eq. 29) 500 nM Est.
KM, cGMPPMCA cGMP concentration at half-maximal activation of PMCA (Eq. 31) 1 μM Est.
KM, cGMPKCa cGMP concentration at half-maximal activation of KCa channels (Eq. 27) 0.55 μM (53)
VM, cGMPKCa Constant for activation of KCa channels by cGMP (Eq. 27) 66.9 mV (53)
KM, NOKCa NO concentration at half-maximal activation of KCa channels (Eq. 27) 200 nM (53)
VM, NOKCa Constant for activation of KCa channels by NO (Eq. 27) 100 mV (53)
VCa Constant for voltage-dependence of KCa channel open probability (Eqs. 26 and 27) −53.7 mV (53)
VB Constant for voltage-dependence of KCa channel open probability (Eqs. 26 and 27) 283.7 mV (53)
kKCa Constant for voltage-dependence of KCa channel open probability (Eq. 26) 30.8 mV (53)
KM, O2SERCA O2 concentration at half-maximal inhibition of SERCA (Eq. 33) 20 μM Est.
KM, H2O2SERCA H2O2 concentration at half-maximal inhibition of SERCA (Eq. 34) 66 μM (24)
KM, O2NAK O2 concentration at half-maximal inhibition of Na+-K+-ATPase (Eq. 36) 1.6 μM Est.
KM, H2O2NAK H2O2 concentration at half-maximal inhibition of Na+-K+-ATPase (Eq. 36) 0.56 mM (16)
KM, H2O2MLCP H2O2 concentration at half-maximal inhibition of MLCP (Eq. 37) 1 μM Est.
αMLCP Constant for H2O2-mediated inhibition of MLCP (Eq. 37) 4.0 See text

SERCA, SR Ca2+-ATPase; MLCP, myosin light chain phosphatase; PMCA, plasma membrane Ca2+-ATPase.

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