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. 2010 Nov 17;300(2):F441–F456. doi: 10.1152/ajprenal.00499.2010

Table 7.

Predicted baseline solute concentrations

Cytosolic Concentrations
Microdomain Concentrations
Case 1 Case 2 Case 1 Case 2
[NO] 93 nM 93 nM 93 nM ∼0
[cGMP] 9.0 μM 9.0 μM 9.0 μM ∼0
[O2] 0.83 nM 0.83 nM 0.83 nM ∼0
[H2O2] 50 nM 50 nM 50 nM ∼0
[Ca] 108 nM 105 nM 154 nM 372 nM
[Na] 8.8 mM 9.2 mM 16.2 mM 20.7 mM
[K] 144 mM 141 mM 143 mM 131 mM
[Cl] 26 mM 23 mM 23 mM 17 mM

Case 1 assumes that the concentration of NO and reactive oxygen species (ROS) in subplasmalemmal microdomains is equal to that in the cytosol, whereas case 2 assumes that NO and ROS microdomain concentrations are negligible.

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