Fig. 7.

Mitochondrial permeability transition pore (mPTP) opening potential of cardiac mitochondria harvested from the LV apex of controls, 2 h after Isop treatment, or 2 h Isop treatment together with either Carv or Quer pretreatment. The abrupt rise in mitochondrial permeability to solutes and ensuing osmotic swelling is assessed by the reduction in absorbance measured spectrophotometrically at 560 nm following mPTP opening induced by CaCl₂. *P < 0.05 vs. controls; †P < 0.05 vs. 2 h Isop. CsA, cyclosporine A.