Table 1.
Incidence of concordant and discordant alternans
| RV1-2 | RV2-3 | LV1-2 | LV2-3 | LV3-4 | ||
|---|---|---|---|---|---|---|
| WT | ||||||
| No drug | Concordant | 8/16 | 0/16 | 0/16 | 8/16 | 0/16 |
| Discordant | 0/16 | 0/16 | 0/16 | 0/16 | 0/16 | |
| Flecainide 10 μM | Concordant | 4/8 | 5/8 | 5/8 | 4/8 | 4/8 |
| Discordant | 2/8 | 1/8 | 1/8 | 0/8 | 0/8 | |
| Quinidine 5 μM | Concordant | 5/8 | 0/8 | 0/8 | 5/8 | 5/8 |
| Discordant | 1/8 | 0/8 | 0/8 | 0/8 | 0/8 | |
| Scn5a+/− | ||||||
| No drug | Concordant | 6/16 | 4/16 | 4/16 | 6/16 | 5/16 |
| Discordant | 6/16 | 4/16 | 3/16 | 4/16 | 3/16 | |
| Flecainide 10 μM | Concordant | 7/8 | 5/8 | 4/8 | 5/8 | 4/8 |
| Discordant | 6/8 | 4/8 | 2/8 | 3/8 | 3/8 | |
| Quinidine 5 μM | Concordant | 6/8 | 3/8 | 2/8 | 4/8 | 3/8 |
| Discordant | 2/8 | 1/8 | 0/8 | 1/8 | 0/8 |
Number of runs in adjacent cardiac regions in wild-type (WT) and Scn5a+/− hearts that resulted in either concordant alternans or discordant alternans. The denominator is the total number of runs at each region.
RV, right ventricle; LV, left ventricle. 1, 2, 3, and 4: regions 1, 2, 3, and 4.