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Simplified schematic diagram of contributions of the CSE/H2S and cyclooxygenase/prostanoid pathways in arteriolar dilation to hypercapnia in newborn brain. COX, prostaglandin cyclooxygenase; AA, arachidonic acid; PGI2, prostacyclin; IP, prostacyclin receptor; PLC, phospholipase C; DAG, diacylglycerol; AC, adenylyl cyclase; PKC, protein kinase C; VDCC, voltage-dependent Ca2+ channel.
