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Reduced gene expression for crosslinking enzymes in discoidin domain receptor 2 (DDR2)-/- tissues. (a) Representative histogram of trivalent lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) crosslinks. (b) Representative lysyl oxidase (LOX), lysyl hydroxylase1 (LH1) and 'secreted protein, acidic and rich in cysteine' (SPARC) mRNA expression levels in skin lysates 7 days after injury (n = 6). *P < 0.05, significantly different compared with the DDR2+/+ group.
