Table 1. FADS1, FADS2 and ELOVL5 enzymatic indexes according to maternal genotypes and LC-PUFA levels in colostrum.
| 11 | 12 | 22 | |||||||
| Major/minor allele | N | Mean (sd) | N | Mean (sd) | N | Mean (sd) | p value* | ||
| FADS1 index | |||||||||
| AA:DGLA | |||||||||
| Gene | SNP | ||||||||
| FADS | rs174537 | G/T | 142 | 1.46 (0.02) | 109 | 1.22 (0.03) | 19 | 0.96 (0.08) | 1.0×10−20 |
| FADS | rs968567 | G/A | 200 | 1.44 (0.02) | 57 | 1.04 (0.03) | 3 | 0.76 (0.08) | 2.4×10−29 |
| FADS | rs2072114 | A/G | 219 | 1.35 (0.02) | 49 | 1.23 (0.04) | 2 | 0.93 (0.04) | 0.0026 |
| FADS | rs526126 | C/G | 160 | 1.37 (0.02) | 66 | 1.25 (0.04) | 2 | 1.06 (0.19) | 0.0031 |
| FADS | rs174626 | T/C | 66 | 1.43 (0.03) | 141 | 1.32 (0.02) | 63 | 1.25 (0.04) | 0.0007 |
| FADS | rs174627 | C/T | 209 | 1.37 (0.02) | 56 | 1.20 (0.04) | 5 | 0.99 (0.14) | 7.5×10−06 |
| FADS | rs174464 | C/T | 116 | 1.41 (0.03) | 103 | 1.26 (0.03) | 19 | 1.20 (0.07) | 7.2×10−05 |
| FADS | rs174468 | G/A | 100 | 1.28 (0.03) | 124 | 1.34 (0.03) | 40 | 1.43 (0.04) | 0.0078 |
| FADS2 indexes | |||||||||
| DGLA:LA | |||||||||
| Gene | SNP | ||||||||
| FADS | rs174537 | G/T | 142 | 0.06 (0.001) | 109 | 0.07 (0.002) | 19 | 0.09 (0.008) | 8.5×10−06 |
| FADS | rs968567 | G/A | 200 | 0.06 (0.001) | 57 | 0.09 (0.003) | 3 | 0.11 (0.016) | 1.1×10−15 |
| FADS | rs174627 | C/T | 209 | 0.06 (0.001) | 56 | 0.07 (0.003) | 5 | 0.08 (0.020) | 0.0129 |
| DHA:EPA | |||||||||
| Gene | SNP | ||||||||
| FADS | rs174602 | A/G | 209 | 1.65 (0.03) | 56 | 1.56 (0.03) | 5 | 1.42 (0.05) | 0.0039 |
| ELOVL5 index | |||||||||
| DPA:EPA | |||||||||
| Gene | SNP | ||||||||
| ELOVL5 | rs2397142 | C/G | 125 | 7.81 (0.31) | 112 | 8.08 (0.42) | 31 | 10.02 (1.28) | 0.0362 |
INMA Sabadell cohort.
Only statistically significant associations are showed.
Major allele:1; minor allele:2. Data are means (standard error). *P-values for additive genetic models assuming a trend per copy of the minor allele.
AA: Arachidonic acid; DGLA: Eicosatrienoic acid; LA: Linoleic acid; DHA: Docosahexaenoic acid; DPA: Docosapentaenoic acid; EPA: Eicosapentanoic acid.