Figure 5. BMP signals negatively regulate Notch activity in olfactory placodal cells.
(A) OP explants (n = 24) cultured alone generated Hes5 +, Delta1 +and Notch1 + cells in a scattered manner. (B) In OP explants cultured together with BMP4 (35 ng/ml) (n = 12), the generation of Hes5 +, Delta1 +and Notch1 + cells was blocked. (C) In OP explants cultured together with Noggin (n = 18), the generation of Hes5 + and Delta1 + cells was increased, while the generation of Notch1 + cells was unaffected.