TABLE 1.

NOAEL and ED50 Values for T Production, StAR, Cyp11a, and insl3 Gene Expression following DPeP or DEHP In Utero Exposure during Sexual Differentiation. DEHP Prenatal Data derived from Howdeshell et al. (2008) and The Postnatal Data from Gray et al. (2009). Values Derived from Dose-response Regression Profiles in the Current Study Used three to six litters per dose group

Endpoint/treatment	ED50 mg/kg/day	NOAEL
T production
DPeP 1 day (GD 17.5)	667	300
T production
DPeP 5 days (GD 14–18)	47	11
DEHP 10 days (GD 8–18)	388.2	100
StAR mRNA expression
DPeP 5 days (GD 14–18)	46	33
insl3 mRNA expression
DPeP 5 days (GD 14–18)	87	33
Cyp11a mRNA expression
DPeP 5 days (GD 14–18)	143	100
DPeP 5-day neonatal and infantile endpoints
AGD at day 2	257	33
Retained nipples/areolae	175	100
Reduced viability	294	33
DEHP neonatal and infantile endpoints
AGD at day 3	521	300
Retained nipples/areolae	785	300
Reduced viability	ND	ND

Note. ND, not determined.