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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Reprod Toxicol. 2010 Oct 16;31(3):344–350. doi: 10.1016/j.reprotox.2010.10.003

Table 2.

Impact of Developmental TCDD Exposure on Reproductive Outcome in MPV-free C57bl/6Mice over Multiple Generations

Exposure Pregnancy Rate Pregnancy Outcome
Full-term Preterm
Vehicle Control1
 conF1 10/10 (100%) 10/102 0/10
 conF3 12/12 (100%) 12/12 0/12
TCDD in utero3
  F1 11/28 (39%) 7/11 4/11
  F3 8/14 (57%) 6/8 2/8
1

Pregnant mice were exposed to corn oil vehicle (control) on E15.5 and control offspring (cF1 mice) mated at 10–12 weeks of age. Offspring of conF1 mice (conF2 mice) were mated at a similar age, as were the conF3 mice.

2

Only a subset of conF1–F3 offspring were used to obtain additional generations of unexposed mice.

3

Pregnant mice were exposed to 10 ug/kg TCDD in corn oil vehicle on E15.5 and singly exposed offspring (F1 mice) were mated at 10–12 weeks of age. Offspring of singly exposed F1 mice (F2 mice) were mated at a similar age, as were the F3 mice.