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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Reprod Toxicol. 2010 Oct 16;31(3):344–350. doi: 10.1016/j.reprotox.2010.10.003

Table 3.

Impact of LPS-Induced Preterm Birth in Adult C57bl/6 Mice with a History of Developmental TCDD Exposure

Mouse Phenotype and Treatment Pregnancy Rate Pregnancy Outcome
Full-Term Preterm
Vehicle Control + 200 uL PBS1
conF1 7/7 (100%) 7/7 0/7
Vehicle Control + 200 ug/kg LPS2
conF1 5/5 (100%) 5/5 0/5
TCDD in utero + 200 ug/kg LPS3
F1 3/6 (50%) 0/3 3/3
1

Pregnant, control mice (conF1) were provided 200 uL PBS by intraperitoneal injection under anesthesia on E16.5 and monitored until delivery.

2

Pregnant, control mice (conF1) were provided 200 mg/kg LPS in 200 uL PBS by intraperitoneal injection under anesthesia on E16.5 and monitored until delivery.

3

Pregnant, adult mice which were exposed to TCDD during their own in utero development (F1), were provided 200 mg/kg LPS in 200 uL PBS by intraperitoneal injection under anesthesia on E16.5 and monitored until delivery.