Table 1.

Most differently transforming metabolites in the three domains. The full list is available at http://sarst.life.nthu.edu.tw/metabolic/SD.csv.

Domain	List of hubs in the descending order of appearance
Archaea (67 spp)	ATP, L-Glutamate, CO2, Acetyl-CoA, L -Glutamine, Pyruvate, NH3, L -Aspartate, AMP, 5P-alpha-D-ribose 1P, S-Adenosyl- L -methionine
Bacteria (895 spp)	CO2, ATP, NH3, Pyruvate, L -Glutamate, Acetyl-CoA, 5P-alpha-D-ribose 1P, CoA, Malonyl-ACP, L -Aspartate, Glutathione, AMP, S-Adenosyl- L -methionine, Glycine
Eukaryotes (113 spp)	L -Glutamate, CO2, Acetyl-CoA, NH3, CoA, ATP, AMP, Glutathione, Pyruvate, Malonyl-ACP, S-Adenosyl- L -methionine, Glycine, D-Galactose, UDP-glucuronate, L -Serine, L -Glutamine

Highlighted metabolites are mentioned in the main text. Abbreviations: P … phosphate; ACP … acyl carrier proteins.