Table 2.
The changed epitopes and mutations of 11 virus-pairs under 4 models
| Virus A | Virus B | Type1 | Changed epitopes | HD2 | Mutation positions | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model one | Model two | Model three | Model four | Epitope A | Epitope B | Epitope C | Epitope D | Epitope E | ||||
| A/PortChalmers/1/73 | A/Singapore/4/75 | S | ABCDE | B | B | B | 9 | 1263 | 160, 189 | 278 | 242 | 83 |
| A/Nanchang/933/95 | A/NewYork/43/96 | S | ABCE | E | none | none | 6 | 122 | 190 | 275 | 57, 92, 262 | |
| A/Alaska/10/95 | A/France/75/97 | S | ABCDE | BC | none | none | 12 | 135 | 128, 165 | 275, 312 | 226 | 262 |
| A/Sydney/5/97 | A/Ireland/10586/99 | S | ABDE | ABD | none | none | 7 | 137, 142 | 192, 194 | 172,226 | 57 | |
| A/Mississippi/1/85 | A/Leningrad/360/86 | V | ABDE | B | B | B+ | 6 | 138 | 156, 159, 188 | 226 | 88 | |
| A/Guizhou/54/89 | A/Beijing/353/89 | V | ABC | A | A | A | 5 | 135, 144, 145 | 159 | 44, | ||
| A/Wellington/1/2004 | A/Victoria/505/2004 | S | ABDE | AD | none | none | 10 | 138, 145 | 189 | 219, 226, 227 | 94 | |
| A/Shangdong/9/93 | A/Pennsylvania/9/93 | S | ABCD | CD | C | C | 12 | 135 | 164 | 53, 276 | 214, 219, 226, 229, 238 | |
| A/England/42/72 | A/PortChalmers/1/73 | V | BDE | B | B | B+ | 6 | 160, 188, 193 | 208 | 63 | ||
| A/NewYork/55/2004 | A/Anhui/1239/2005 | V | ABD | B | B | B+ | 7 | 138, | 156, 160, 193 | 219, | 138, | |
| A/Shanghai/16/89 | A/Beijing/353/89 | V | AB | A | A | A | 3 | 135, 145 | 159 | |||
1V represents antigenic variant and S represents similar virus.
2 denote hamming distance of a pair sequences
3 Bold is the antigenic critical position.