Table 3.

Design and key summary findings of experimental studies evaluating N-acetylcysteine (NAC) in liver transplantation (n= 4)

First author/year	Species	Experimental model	NAC intervention	Principal outcome
Walcher et al. 199539	Rat	Livers stored for 20 h in University of Wisconsin (UW) solution and transplanted orthotopically	Donors 150 mg/kg NAC PLUS 83 mg/kg NAC at start of recipient operation.	No change in early microvascular failure after liver transplantation.
Koeppel et al. 199640	Rat	Orthotopic liver transplant following cold storage in University of Wisconsin (UW) solution for 24h	400 mg/kg NAC before hepatectomy and after re-perfusion in recipients.	NAC reduced non-perfused sinusoids and improved bile flow.
Regueira et al. 199741	Pig	Controlled trial of NAC in OLTX	3 g NAC to donor 1 h before warm ischemia	Reduced SGOT rise, Improved coagulation, better survival rate and reduce graft nonfunction.
Manika et al. 199942	Pig	RCT of porcine liver OLTX	150 mg/kg NAC infusion to donor and recipient.	No effect of NAC on liver histology or graft survival.

OLTX, orthotropic liver transplant; SGOT, serum glutamic oxaloacetic transaminase; RCT, randomized controlled trial.