Table 3.
Summary of the sensitivity, specificity, accuracy, positive and negative predictive values of non-invasive imaging modalities used to discriminate between benign and malignant dominant strictures in patients with primary sclerosing cholangitis
| Author(s) (year) | Patients, n | Diagnostic test | Sensitivity | Specificity | Accuracy | PPV | NPV |
|---|---|---|---|---|---|---|---|
| Majoie et al. (1995)56 | 23 | US (intrahepatic DS) | 77% | NA | NA | NA | NA |
| Lee et al. (1995)57 | 85 | US (extrahepatic DS) | 94% | NA | NA | NA | NA |
| Macchi et al. (2004)59 | 16 | CT cholangiography (extrahepatic DS) | 94% | NA | NA | NA | NA |
| Eracleous et al. (2005)60 | 31 | CT cholangiography (intrahepatic DS) | 100% | NA | NA | NA | NA |
| Silverman et al. (1994)61 | 34 | MRC | 85% | 92% | NA | 85% | NA |
| Moff et al. (2006)62 | 36 | MRC | 85–91% | 85–96% | NA | NA | NA |
| Berstad et al. (2006)68 | 66 | MRC | 77–82% | 81–93% | 79–86% | 86–94% | 71–78% |
PPV, positive predictive value; NPV, negative predictive value; NA, not available; US, ultrasound; DS, dominant strictures; CT, computed tomography; MRC, magnetic resonance cholangiography