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. 2011 Feb 7;108(8):3216–3221. doi: 10.1073/pnas.1010334108

Fig. 5.

Fig. 5.

Amelioration of lung defects of the Nedd4L conditional KO mice with amiloride treatment. Newborn mice were treated three times daily (from day 1 to 10) with amiloride, or water, and lungs of mice were sacrificed on day 11 analyzed by H&E staining. (A and B) KO (Nedd4Lf/f;SPC-rtTA;teto-Cre) mice treated with (A) H2O or (B) amiloride, showing whole lungs as well as a higher magnification of lung segments from each (Lower). Note the areas of inflammation in water-treated KO animals (arrows in A), not seen in amiloride-treated KO mice (B). (C and D) Control mice treated with (C) H2O or (D) amiloride. Results are representative of data from five to six mice per treatment.