The Kv channel pore architecture. Monomer of the Kv1.2 pore region, reproduced from Long et al. (13). The turret is depicted in blue, the pore helix in red, the selectivity filter in yellow, the loop preceding S6 (loop-S6) in green, and transmembrane segments S5 and S6 in gray. The dashed circle highlights the secondary and tertiary architecture investigated in this paper.