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CHK1 depletion was the most potent inhibitor of neuroblastoma growth. (A) Growth curves of neuroblastoma cell lines SKNAS and KELLY treated with siCHK1 and siGAPDH and the positive control siPLK1. (B) Western blot of siCHK protein depletion in KELLY and SKNAS. CHK1 depletion does not significantly inhibit the growth of control RPE1 cells (C) despite adequate mRNA (D) and protein depletion (E).
