Fig. 2.

HFD-induced liver steatosis in SMRT^mRID1 mice. (A) Hematoxylin and eosin staining of histological sections from liver in HFD-challenged WT and SMRT^mRID1 mice. (B) Liver weight was increased in SMRT^mRID1 mice. (C) The levels of hepatic triglyceride and cholesterol in WT and SMRT^mRID1 mice (n = 5). (D) The level of serum ALT in WT and SMRT^mRID1 mice (n = 5). (E) Hepatic gene expression of nuclear receptors, lipogenesis, glucose, and cholesterol/bile acid metabolism in WT and SMRT^mRID1 mice. All error bars are SD. *P < 0.05; **P < 0.01; n.s., not significant.