Fig. 5.

SMRT^mRID1 mice are less active, expend less energy, and are more glycolytic than oxidative. (A) Carbon dioxide production (Upper) and oxygen consumption (Lower). (B) Cumulative ambulatory counts in WT and SMRT^mRID1 mice. (C) RQ in WT and SMRT^mRID1 mice. (D) Cellular bioenergetics in SVF cells from WT and SMRT^mRID1 mice. (E) Fasting serum lactate level in WT and SMRT^mRID1 mice. (F and G) Gene expression of NRs, uncoupling protein, FA oxidation, OXPHOS, glycolysis, PGC1α and -β, and DNMTs in skeletal muscles from WT and SMRT^mRID1 mice. All error bars are SD. *P < 0.05; **P < 0.01; n.s., not significant.