12(S) hydroxyeicosatetraenoic acid concentrations in the sciatic nerve (A) and spinal cord (B) of control and diabetic mice maintained with or without PMI-5011 treatments. C, control; D, diabetic; T, PMI-5011 treatment; 12(S)HETE, 12(S) hydroxyeicosatetraenoic acid. Mean ± SEM, n=7-9 per group. *P<0.05 and **P<0.01 vs. the non-diabetic control group. #P<0.05 vs. the untreated diabetic group.