Table III.

Indices of small sensory nerve fiber function in non-diabetic and diabetic mice maintained with or without PMI-5011 treatment

Variables	Control	Control with PMI-5011	Diabetic	Diabetic with PMI-5011
Baseline (before induction of STZ-diabetes)
Paw withdrawal latency (sec)	8.9±0.3
Tail-flick response latency (sec)	2.62±0.05
Mechanical withdrawal threshold (g)	121±3.0
Tactile response threshold (g)	2.02±0.11
12-week time point (prior to interventions)
Paw withdrawal latency (sec)	9.3±0.3		16.9±1.0a
Tail-flick response latency (sec)	2.7±0.1		4.5±0.3a
Mechanical withdrawal threshold (g)	116.3±1.5		145.6±4.1a
Tactile response threshold (g)	1.9±0.2		0.9±0.1a
19-week time point (final measurements)
Paw withdrawal latency (sec)	10±0.5	9.1±0.4	15.6±1.1a	12.8±0a,c
Tail-flick response latency (sec)	2.5±0.1	2.5±0.1	4.8±0.3a	3.2±0a,c
Mechanical withdrawal threshold (g)	107.3±3.3	108.1±2.3	144.8±5.4a	119.3±2.5a,c
Tactile response threshold (g)	1.7±0.2	1.6±0.1	0.8±0.1a	1.1±0.04a,b

Data are expressed as mean ± SEM, n=7-10 per group.

^aP<0.01 vs. the non-diabetic controls

^bP<0.05

^cP<0.01 vs. the untreated diabetic group.