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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Bioorg Med Chem. 2010 Nov 9;18(24):8592–8599. doi: 10.1016/j.bmc.2010.10.018

Figure 6.

Figure 6

Ex vivo film autoradiography. (A) [11C]MeDAS binding to myelinated corpus callosum in mouse brain (coronal). Arrows show myelinated corpus callosum labeled by [11C]MeDAS. (B) The autoradiographic visualization was further confirmed by using MRI as reference, indicating that the autoradiographic visualization was consistent with histological staining of myelinated region. (C) No distinct labeling of the corpus callosum was observed after pretreatment of the mice with unlabeled BDB (5 mg/kg), indicating that [11C]MeDAS binds to myelinated corpus callosum with high selectivity and specificity.