Table 2.

Risk of cardiovascular mortality by depression score and physical activity

Group†	No of deaths	Person- years	Incidence per 1000 person-years	Unadjusted/univariate HR (95% CI)	Demographic adjusted HR (95% CI)*	Multivariable adjusted HR (95% CI)‡
Depressive symptoms§
Low (n=4600)	709	44 047	16	1.0 (reference)	1.0 (reference)	1.0 (reference)
High (n=1252)	467	16 605	28	1.67 (1.49 to 1.88)	1.63 (1.45 to 1.84)	1.27 (1.12 to 1.44)
Physical activity score (PAS)
Group IV: 12–15 (n=739)	59	6695	9	1.0 (reference)	1.0 (reference)	1.0 (reference)
Group III: 8–11 (n=2546)	313	24 048	13	1.45 (1.10 to 1.92)	1.36 (1.03 to 1.80)	1.23 (0.93 to 1.63)
Group II: 4–7 (n=1914)	449	21 336	21	2.24 (1.71 to 2.94)	2.16 (1.64 to 2.84)	1.71 (1.30 to 2.26)
Group I: 0–3 (n=653)	355	8574	41	4.25 (3.22 to 5.61)	3.59 (2.70 to 4.77)	2.17 (1.62 to 2.91)

All p values<0.001 except PAS group III: p=0.008 (unadjusted), p=0.031 (demographic) and p=0.143 (multivariable).

^*Adjusted for age, race and gender.

^†The number of participants in each group is taken from baseline.

^‡Adjusted for age, race, gender, clinic location (four sites), education (less than high school, high school, beyond high school), body mass index (underweight, normal, overweight, obese), smoking (never, former, current), alcohol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, diabetes, hypertension, coronary heart disease, congestive heart failure, stroke and antidepressant medication use.

^§Depressive symptoms based on the Center for Epidemiological Studies-Depression Scale (10-item version): low (score 0–7) and high (score ≥8).