Table 2. Multivariate regression analysis of risk factors for acute lung injury.
| Predisposing conditions | OR† | 95% CI† | p-value |
|---|---|---|---|
| Shock | 2.2 | 1.2–3.7 | 0.008 |
| Aspiration | 2.2 | 1.1–4.3 | 0.02 |
| Sepsis | 1.4 | 0.9–2.4 | 0.14 |
| Pneumonia | 0.3 | 0.02–1.7 | 0.3 |
| High-risk surgery | |||
| Thoracic (noncardiac) | 0.9 | 0.1–3.2 | 0.9 |
| Orthopedic spine | 2.1 | 0.9–4.6 | 0.07 |
| Acute abdomen | 2.5 | 1.1– 5.6 | 0.03 |
| Cardiac | 3.7 | 2.0–7.1 | <0.001 |
| Aortic vascular | 5.9 | 2.5–13.0 | <0.001 |
| High-risk trauma | |||
| Traumatic brain injury | 3.6 | 2.0–6.8 | <0.001 |
| Smoke inhalation | 2.5 | 0.8–4.1 | 0.44 |
| Near drowning | 5.4 | 0.06–6.6 | 0.50 |
| Lung contusion | 1.5 | 0.6–3.4 | 0.36 |
| Multiple fractures | 1.9 | 0.8–4.1 | 0.12 |
| Risk modifiers | |||
| Male gender | 1.0 | 0.7–1.5 | 0.91 |
| Alcohol abuse | 1.7 | 0.9–2.9 | 0.08 |
| Obesity (BMI >30) | 1.8 | 1.2–2.5 | 0.004 |
| Chemotherapy | 1.6 | 0.6–3.6 | 0.32 |
| Diabetes mellitus‡ | 0.6 | 0.2–1.2 | 0.14 |
| Smoking | 1.1 | 0.7–1.5 | 0.4 |
| Emergency surgery | 3.1 | 1.6–5.9 | <0.01 |
| Tachypnea (RR >30/min) | 2.0 | 1.1–3.5 | 0.02 |
| SpO2 <95% | 1.4 | 1.0–2.1 | 0.08 |
| FiO2 >0.35 (>4 l/min) | 2.8 | 1.9–4.1 | <0.001 |
| Hypoalbuminemia | 1.6 | 1.0–2.4 | 0.03 |
| Acidosis (pH <7.35) | 1.7 | 1.1–2.7 | 0.02 |
†
Logistic regression coefficients presented in original table converted to ORs in this reproduction.
‡
Only in sepsis.
OR: Odds ratio.
Reprinted from [41] with permission of the American Thoracic Society.