Table 1.
Demographics and baseline characteristics.
| Characteristics | rFVIIa (n = 72) | Non‐rFVIIa (n = 256) | p‐Value |
| Male n (%) | 48 (67) | 185 (72.3) | 0.35 |
| Age (years) | 34 (23‐48)* | 35 (22‐52)* | 0.8854 |
| ISS | 43 (±15) | 41 (±15) | 0.2971 |
| Head AIS | 2 (0‐5)* | 3 (0‐5)* | 0.0765 |
| Penetrating n (%) | 33 (31) | 57 (22) | 0.1461 |
| Hemoglobin (g/L) | 98 (±27) | 101 (±23) | 0.3888 |
| Platelet count (× 104) | 169 (±99) | 192 (±95) | 0.0854 |
| ipH† | 7.20 (±0.18) | 7.26 (±0.17) | 0.0266 |
| Base deficit‡ | 10 (±6.6) | 7 (±5.4) | 0.0018 |
| Lactate§ (mmol/L) | 9 (±3.8) | 7 (±3.4) | 0.0166 |
| Fibrinogen¶ (g/L) | 0.86 (±0.5) | 0.93 (±0.5) | 0.4100 |
| INR** | 1.4 (1.2‐1.9)* | 1.3 (1.2‐1.7)* | 0.0665 |
| Transfusion rate (RBC units/h) | 3.1 (±1.7) | 2.1 (±1.0) | <0.0001 |
Mean (± standard deviation) and t‐test used.
*
Medians and IQR are reported and Mann–Whitney U test used; χ2 or Fisher's exact test used for categorical variables.
†
12 missing in the control group and 1 in the rFVIIa group.
‡
109 missing in the control group and 4 in the rFVIIa group.
§
160 missing in the control group and 36 missing in the rFVIIa group.
¶163 missing in the control group and 20 missing in the rFVIIa group.
**
16 missing in the control group and none missing in the rFVIIa group.
AIS = Abbreviated Injury Scale Score; INR = international normalized ratio; ipH = initial pH; ISS = Injury Severity Score; RBC = red blood cells; rFVIIa, recombinant factor VIIa.