Table 5. Diagnostic Accuracy of Rest MPI in Patients With Acute Chest Pain and a Nonischemic ECG.

Reference	n	Radiopharmaceutical	Sensitivity, %	Specificity, %	NPV, %	Outcome
Varetto et al111	64	Tc-mibi	100	92	100	CAD
Hilton et al112	102	Tc-mibi	94	83	99	CAD/AMI
Tatum et al113	438	Tc-mibi	100	78	100	AMI
Kontos et al116	532	Tc-mibi	93	71	99	AMI
Heller et al115	357	Tc-tet	90	60	99	AMI
Kontos et al114	620	Tc-mibi	92	67	99	AMI
Udelson et al*71	1215	Tc-mibi	96	NR	99	AMI
Schaeffer et al117	479	Tc-mibi	77	92	99	ACS

NPV indicates negative predictive value; AMI, acute MI; Tc-mibi, ^99mTc-sestamibi; Tc-tet, ^99mTc-tetrofosmin; and NR, not reported.

^*Randomized controlled trial.

Adapted from Kontos and Tatum.¹⁰⁷