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[3H]-PK11195 binding parameters(a) in mouse membranes.
| Brain: | Kd (nM) | Bmax (fmol/mg protein) |
|---|---|---|
| ob/ob Mutant | 1.75 ± 0.3 | 403.5 ± 12.6 (*) |
| Wild Type | 1.8 ± 0.2 | 329.5 ± 16.0 |
| Kidney: | Kd (nM) | Bmax (fmol/mg protein) |
| ob/ob Mutant | 1.9 ± 0.2 | 19550 ± 1180 |
| Wild Type | 2.0 ± 0.3 | 20260 ± 2017 |
(a): Data are presented as mean ± SD of n = 4 separate experiments in brain and kidney membrane preparations carried out in ob/ob and WT animals as indicated in the Methods sections. (*): Student t-test, p < 0.05.
