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. 2011 Feb 24;7(2):e1001315. doi: 10.1371/journal.pgen.1001315

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Callahan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A) All PDBs for the source organism D. melanogaster were downloaded at http://www.pdb.org/, with homologs excluded at 90% identity. These crystal structures were used to estimate a relationship between the structural distance between the atoms of amino acids as a function of their separation along the primary sequence. The solid blue line indicates the mean distance, while the dashed lines indicate first and third quartiles. Structural distance increases quickly with sequence distance, but the increase saturates at a sequence distance of around amino acids. B) The phylogenic tree of the Drosophilid species we are considering (adapted from that at http://rana.lbl.gov/drosophila/).

Inline graphic — A) All PDBs for the source organism D. melanogaster were downloaded at http://www.pdb.org/, with homologs excluded at 90% identity. These crystal structures were used to estimate a relationship between the structural distance between the atoms of amino acids as a function of their separation along the primary sequence. The solid blue line indicates the mean distance, while the dashed lines indicate first and third quartiles. Structural distance increases quickly with sequence distance, but the increase saturates at a sequence distance of around amino acids. B) The phylogenic tree of the Drosophilid species we are considering (adapted from that at http://rana.lbl.gov/drosophila/).