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. 2011 Feb 24;7(2):e1001301. doi: 10.1371/journal.ppat.1001301

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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A) The V1/V2 regions of 92Ug037 (subtype A) and 93MW959 (subtype C) aligned with HXBII V1/V2. PNGΔs associated with transmission are designated using HXBII numbering. PNGs that appear in 92Ug037 and 93MW959 are highlighted in red. PNGΔs introduced into each protein by N/Q substitution appear directly below. B) α₄β₇-reactivities of 92Ug037 w.t. gp120 and PNGΔ mutants are reported as mean fluorescence intensity (MFI). C) α₄β₇-reactivities of 93MW959 w.t. gp120 and PNGΔ mutants. Error bars report the standard deviation between two replicates, and results are representative of three independent experiments using independent donor CD4⁺ T cells.

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