Figure 3. Effect of PNGΔs in the C3/V4 region on the α4β7-reactivity of 92Ug037 gp120.
A) The positions of transmission-linked PNGs in the C3/V4 region of subtype A gp120s are highlighted in red in the C3/V4 region of 92Ug037 and N/Q substitutions are listed directly below. B) α4β7-reactivity of each 92Ug037 PNGΔ mutant was compared to w.t 92Ug037 gp120 and reported as mean fluorescence intensity (MFI) 92Ug037N144Q was included for reference. Results are representative of three independent experiments using independent donor CD4+ T cells.