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. 2011 Feb 18;17:526–532.

Figure 3.

Figure 3

Effects of inhibitors of MAPK or NF-κB signaling on the poly(I:C)-induced expression of MMP-1 and MMP-3 in human corneal fibroblasts. Cells were incubated first for 1 h in the absence or presence of PD98059, SB203580, or JNK inhibitor II (each at 10 µM) or of IKK-2 inhibitor (1 µM) and then for 24 h in the additional absence or presence of poly(I:C) at 1 µg/ml. The culture supernatants were then collected and subjected to immunoblot analysis with antibodies to MMP-1 and to MMP-3. Data are representative of three independent experiments.