Table 1. Statistical analysis of relapse in diffuse large B cell lymphoma patients whose miR-92a levels were determined at complete response phase.
univariate | multivariate | |||||||
Factors at diagnosis | No. (n = 34*) | Relpased (n = 6) | P value | odds ratio | 95% CI | P value | Corrected odds ratio | 95% CI |
Sex | ||||||||
male | 13 | 1 | .231 | 0.267 | 0.02743 to 2.592 | .833 | 1.3037 | 0.066 to 8.971 |
female | 21 | 5 | ||||||
Age | ||||||||
≥60 years | 20 | 4 | 1 | 1.5 | 0.2346 to 9.593 | .50 | 0.418 | 0.03 to 5.287 |
<60 years | 14 | 2 | ||||||
LDH | ||||||||
Elevated | 16 | 4 | .289 | 2.667 | 0.4170 to 17.05 | .673 | 1.625 | 0.170 to 15.522 |
Normal | 18 | 2 | ||||||
B symptoms | ||||||||
Yes | 16 | 3 | .874 | 1.154 | 0.1976 to 6.738 | .853 | 0.730 | 0.026 to 20.544 |
No | 18 | 3 | ||||||
Clinical stage | ||||||||
III+IV | 18 | 5 | .18 | 5.769 | 0.5946 to 55.98 | .062 | 23.189 | 0.858 to 629.583 |
I+II | 16 | 1 | ||||||
International Prognostic Index | ||||||||
high + high-int | 14 | 3 | .628 | 1.545 | 0.2629 to 9.085 | .972 | 0.943 | 0.038 to 23.744 |
low + low int | 20 | 3 | ||||||
Plasma miR-92a | ||||||||
Low (<0.2165) | 12 | 5 | .007 | 15 | 1.486 to 151.4 | .020 | 16.232 | 1.562 to 168.725 |
Normal (≥0.2165) | 22 | 1 |
Abbreviations: CI, confidence interval; LDH, lactate dehydrogenase.
*Patients who had been followed for more than 6 months and who did not receive any hematopoietic stem cell transplantation were analyzed.